In dimethyl sulfoxide solvated 9-(2-carb-oxy-2-cyano-vin-yl)julolidine, C(16)H(16)N(2)O(2)·C(2)H(6)OS, the essentially planar -CH=(CN)-CO(2)H substituent (r.m.s. deviation = 0.014 Å) is almost coplanar with respect to the benzene ring, the dihedral angle between the two planes being 0.48 (2)°. The conformations of the fused, non-aromatic rings were found to be half-chair. In the crystal, the acid molecule forms a hydrogen bond to the O atom of the solvent mol-ecule. The acid mol-ecule is disordered over two positions with respect to the methyl-ene C atoms in a 1:1 ratio. The crystal studied was found to be a racemic twin.
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http://dx.doi.org/10.1107/S1600536812043383 | DOI Listing |
J Exp Pharmacol
January 2025
Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Purpose: This study aims to provide new insights into the potential of oyster mushroom () ethanolic extract in preventing obesity through the inhibition of expression and modulation of methylation level on promoter during 3T3-L1 adipocyte differentiation.
Methods: This in vitro quantitative experimental study was conducted by treating the 3T3-L1 cell line differentiated using 0.5 mM methyl-isobutyl-xanthine, 1 μM dexamethasone, and 10 μg/mL insulin-containing medium with oyster mushroom ethanolic extract.
Stomatologiia (Mosk)
January 2025
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Objective: Study on the impact of medical wound dressing compositions on reference strains of microorganisms in vitro conditions.
Materials And Methods: The study compared the antimicrobial activity of three types of dressing materials (DM): iodoform gauze bandage, DM with furagin and sodium alginate, DM from hydrogel with dimexide and silver nitrates. Gauze bandage with chlorhexidine was used as a control.
Iran J Pharm Res
June 2024
Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Insulin resistance is an important pathological hallmark of Parkinson's disease (PD). Proinflammatory cytokines during neuroinflammation decrease insulin sensitivity by suppressing insulin signaling elements. Toll-like receptor 4 (TLR4), the main receptor involved in neuroinflammation, is also associated with the pathogenesis of PD.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
February 2025
Department of Chemistry, Science Faculty, Karabuk University, Karabuk, Turkey.
In this study, four novels 2,5,6-trisubstituted imidazothiadiazole derivative ligands and their Ag(I) complexes were synthesized and characterized using various spectroscopic analysis techniques. First, imidazo[2,1-b][1,3,4]thiadiazole derivative (3) was obtained from the reaction of 5-amino-1,3,4-thiadiazole-2-thiol with benzyl bromide in the presence of KOH in an ethanolic medium. In the next step, the resultant compound reacted sequentially with four substituted phenacyl bromide derivatives (4a-4d) under refluxed ethanol for 24 h to obtain substituted 2-(benzylthio)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole derivatives (5-8).
View Article and Find Full Text PDFAdv Mater
January 2025
School of Energy and Power Engineering, Beihang University, Beijing, 100191, China.
Perovskite smart windows (PSWs) are widely investigated owing to excellent thermochromic properties, while restricted by poor transition performance and cycle stability. Herein, dimethyl sulfoxide vapor is utilized as an induction reagent for rapid reversible switching at room temperature between the colored and bleached phases. To obtain PSWs with different optical properties and transition performance, red CsPbIBr, yellow RbCsPbIBr and brown CsSnPbIBr are prepared through alloying.
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