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The role of artificial intelligence in gynecologic and obstetric emergencies.
Eur J Obstet Gynecol Reprod Biol
January 2025
Department of Gynecology and Obstetrics, University Clinic Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. Electronic address:
Objective: To investigate the potential of artificial intelligence (AI) in emergency medicine, focusing on its utility in triaging and managing acute gynecologic and obstetric emergencies.
Methods And Materials: This feasibility study assessed Chat-GPT's performance in triaging and recommending management interventions for gynecologic and obstetric emergencies, using ten fictive cases. Five common conditions were modeled for each specialty.
Antimelanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis: clinical features and outcomes in a racially diverse patient cohort.
BMC Rheumatol
January 2025
Montefiore Medical Center, Albert Einstein College of Medicine, Rheumatology, Bronx, NY, USA.
Background: The anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis is known for its association with rapidly progressive interstitial lung disease (RP-ILD) and ulcerative skin lesions, often presenting with or without muscle involvement. The aim of this study was to identify distinct clinical and laboratory features that could be used to evaluate disease progression in an ethnically diverse cohort of anti-MDA5 dermatomyositis patients at a U.S.
View Article and Find Full Text PDFStage-specific efficacy of osimertinib in treatment-naïve EGFR-mutant non-small cell lung cancer according to baseline genetic alterations in circulating tumor DNA.
Invest New Drugs
January 2025
Center for Biomedical Sciences, Wakayama Medical University, Wakayama, Japan.
The impact of clinical stage on the effectiveness of osimertinib for epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) remains unexamined. We investigated osimertinib therapeutic efficacy variation between stage IVA or lower and stage IVB EGFR mutation-positive lung cancers, focusing on differences in pretreatment co-occurring genetic alterations in circulating tumor DNA. This was a secondary analysis of the ELUCIDATOR study, a multicenter prospective observational study in Japan that assessed the mechanisms underlying resistance to osimertinib as a first-line treatment for advanced NSCLC with EGFR mutations.
View Article and Find Full Text PDFAbrupt changes in biomass burning during the last glacial period.
Nature
January 2025
Institute of Arctic and Alpine Research, University of Colorado, Boulder, CO, USA.
Understanding the causes of past atmospheric methane (CH) variability is important for characterizing the relationship between CH, global climate and terrestrial biogeochemical cycling. Ice core records of atmospheric CH contain rapid variations linked to abrupt climate changes of the last glacial period known as Dansgaard-Oeschger (DO) events and Heinrich events (HE). The drivers of these CH variations remain unknown but can be constrained with ice core measurements of the stable isotopic composition of atmospheric CH, which is sensitive to the strength of different isotopically distinguishable emission categories (microbial, pyrogenic and geologic).
View Article and Find Full Text PDFAssociations between genetic variations in oxytocin pathway genes and hippocampal volume: Insights from the UK Biobank.
Cortex
December 2024
Department of Psychology, Stockholm University, Stockholm, Sweden; Stockholm University Brain Imaging Centre (SUBIC), Stockholm, Sweden; Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden. Electronic address:
The role of oxytocin-related genes in social-cognitive function has been previously established, but structural brain mechanisms underlying this link remain poorly understood. Utilizing a substantial dataset from the UK Biobank (N ≈ 30,000), this research determined associations between variations in ten single nucleotide polymorphisms (SNPs) within three oxytocin pathway genes (i.e.
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