Oral submucous fibrosis (OSMF) is an insidious chronic progressive disease of the oral cavity which is considered as a precancerous condition. The suggested aetiological factor is the practice of certain customs/habits of the inhabitants of South East Asia. As the disease progresses, the oral mucosa becomes stiff due to the formation of fibrotic bands in the cheek, ultimately leading to reduced mouth opening and trismus. The early form of the disease can be treated by medicinal means, however, advance form needs surgical excision of the fibrotic tissue bands. The defect created due to the excision needs to be repaired by various grafts including split thickness skin grafting, bilateral nasolabial flaps, palatal island flaps, tongue flaps, buccal fat pad graft and temporalis muscle flap graft. We present the management of trismus following OSMF by various surgical approaches in three cases.
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http://dx.doi.org/10.1136/bcr-2012-007871 | DOI Listing |
Ear Nose Throat J
January 2025
Department of Dentistry, Zydus Medical College and Hospital, Dahod, Gujarat, India.
Int J Biol Macromol
December 2024
Center for Biotechnology, Anna University, Chennai 600 025, India. Electronic address:
Alpha-ketoglutarate (αKG) dependent Lysyl hydroxylase (LH) is a critical enzyme in the post-translational conversion of lysine into hydroxylysine in collagen triple helix and telopeptide regions. Overexpression of LH increases collagen hydroxylation and covalent cross-linkage, causing fibrosis. Currently, no drugs are available to inhibit LH potentially.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
December 2024
Department of Periodontology, HKDET'S Dental College, Hospital and Reaserch Institute, Humnadad, Karnataka, India.
Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder (PMD) characterized by a high rate of malignant transformation (MT). OSMF exhibits atrophic epithelium yet has a high proliferation rate. Both p53 and Ki67 are nuclear proteins associated with cell proliferation, detectable in the early stages of oral cancer (OC).
View Article and Find Full Text PDFJ Nanobiotechnology
December 2024
Department of Oral & Maxillofacial Surgery, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The transformation of fibroblasts to myofibroblast is the key pathological change in the development of OSF.
View Article and Find Full Text PDFCell Biochem Biophys
December 2024
Department of Periodontal Mucosa, Changsha Stomatological Hospital, Changsha, Hunan, 410004, P.R. China.
Oral submucous fibrosis (OSF) is a precancerous lesion of the oral cavity. Areca nut consumption can cause OSF through sustained activation of buccal mucosal fibroblasts (BMFs). This study explored the effect of curcumin on arecoline-induced BMF activation and its mechanism of action.
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