AI Article Synopsis
- IL-33 is a newly identified cytokine that plays a significant role in regulating both innate and adaptive immune responses, making it important in various diseases and immune reactions.
- It belongs to the IL-1 family and signals through the ST2L receptor, influencing various immune cells.
- The review highlights the importance of IL-33/ST2 in the immune response to different pathogens like parasites and bacteria, as well as responses to other injuries.
Article Abstract
Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.
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| http://dx.doi.org/10.1007/s00005-012-0208-8 | DOI Listing |
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