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A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions.
JACC Cardiovasc Interv
March 2025
Clinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA; Division of Cardiology, Department of Medicine, Columbia University Medical Center/NewYork-Presbyterian Hospital, New York, New York, USA.
Background: Severe calcification is the morphology most strongly associated with stent underexpansion.
Objectives: The aim of this study was to revise an optical coherence tomography (OCT)-derived calcium score to predict stent underexpansion in severely calcified lesions (angle >270°) using a point-based system.
Methods: A retrospective observational study was conducted in which 250 de novo lesions undergoing OCT-guided stenting, with angiographically visible calcium and optical coherence tomographic maximum superficial calcium angle >270°, not subjected to atherectomy or specialty balloon treatment before stent implantation, were randomly divided into derivation (n = 167) and validation (n = 83) cohorts.
Assessment of the prognostic performance of TIMI, PAMI, CADILLAC and GRACE scores for short-term major adverse cardiovascular events in patients undergoing emergent percutaneous revascularisation: a prospective observational study.
BMJ Open
March 2025
National Institute of Cardiovascular Diseases, Karachi, Pakistan.
Objectives: Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge. This study aims to assess the effectiveness of four established risk scores in predicting short-term MACE after primary PCI.
Design: Prospective observational study.
Association of COMT genetic polymorphism with neuromodulation treatment response in women with fecal or urinary incontinence.
Am J Obstet Gynecol
March 2025
Social, Statistical, & Environmental Sciences, RTI International, Research Triangle Park, NC, United States.
Background: Prior studies have failed to demonstrate clinical or statistical difference in fecal incontinence (FI) symptom improvement with neuromodulation by percutaneous tibial nerve stimulation (PTNS) vs sham. The results of these studies may be indicative of a placebo or sham effect and led us to investigate possible genetic biomarkers of placebo response among women with FI.
Objective: To evaluate the relationship between response to PTNS or sham and genetic polymorphisms associated with placebo response in women with FI.
Feature extraction and prediction of spinal cord stimulation evoked compound action potentials in humans.
J Neural Eng
March 2025
Department of Neurosurgery, University of Minnesota, 500 SE Harvard St, Minneapolis, Minnesota, 55455, UNITED STATES.
Introduction Evoked compound action potentials (ECAPs) during spinal cord stimulation (SCS) may be useful in the treatment of chronic pain as a control signal for closed-loop neuromodulation. However, considerable inter-individual variability in evoked responses requires robust methods in order to realize effective, personalized pain management. These methods include artifact removal, feature extraction, classification, and prediction.
View Article and Find Full Text PDF[Mortality in patients with ST-segment elevation myocardial infarction in Germany : Comparison of routine data vs. quality assurance vs. registry].
Herz
March 2025
Medizinische Klinik B, Klinikum Ludwigshafen, Ludwigshafen, Deutschland.
The recording of mortality after acute myocardial infarction can be based on different data, some of which yield very different results. These differences are due to a number of factors, including the definition of acute myocardial infarction, patient selection and the methods used to determine mortality. While routine data are primarily used for billing purposes, procedural data for coronary angiography and percutaneous coronary intervention (PCI) are used for external quality assurance and therefore only include patients who undergo invasive diagnostic procedures.
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