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A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome.
Annu Rev Physiol
February 2024
Center for Inflammation Sciences and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA; email:
Article Synopsis
- The endothelium, once thought to be a static barrier, is now recognized as a crucial, active tissue that plays a vital role in maintaining the health of organs, particularly in the lungs.
- In healthy individuals, lung endothelial cells (ECs) help maintain balance by promoting processes like vasodilation and reducing inflammation.
- However, under stress from infections or environmental factors, these cells undergo significant changes that contribute to the development of acute respiratory distress syndrome (ARDS), leading to severe inflammation, lung fluid accumulation, and potentially fatal multi-organ dysfunction.
The Anti-Programmed Cell Death Protein-1/ Programmed Death-Ligand 1 Me-Too Drugs Tsunami: Hard To Be Millennials Among Baby Boomers.
J Thorac Oncol
January 2023
Medical Oncology Department Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Was there an improvement in the years of life lost (YLLs) for non-communicable diseases in the Soma and Minamisoma cities of Fukushima after the 2011 disaster? A longitudinal study.
BMJ Open
April 2022
Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Japan.
Objectives: This study aimed to determine cause-specific years of life lost (YLL) changes between predisaster and postdisaster in disaster-affected municipalities, compared with the national average. We estimated the YLL in Soma and Minamisoma cities (the subject area) in Fukushima, Japan, where the tsunami and the nuclear accident hit in 2011.
Participants: We used vital registration records from a national survey conducted between January 2006 and December 2015.
Respiratory Infections Following Earthquake-Induced Tsunamis: Transmission Risk Factors and Lessons Learned for Disaster Risk Management.
Int J Environ Res Public Health
May 2021
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Earthquake-induced tsunamis have the potential to cause extensive damage to natural and built environments and are often associated with fatalities, injuries, and infectious disease outbreaks. This review aims to examine the occurrence of respiratory infections (RIs) and to elucidate the risk factors of RI transmission following tsunamis which were induced by earthquakes in the last 20 years. Forty-seven articles were included in this review and referred to the RIs emergence following the 2004 Sumatra-Andaman, the 2009 Samoa, and the 2011 Japan earthquakes.
View Article and Find Full Text PDFPost-COVID lung fibrosis: The tsunami that will follow the earthquake.
Lung India
March 2021
Department of Pulmonary Medicine, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
The SARS-CoV-2 pandemic has already infected in excess of 50 million people worldwide and resulted in 1.2 million deaths. While the majority of those infected will not have long-term pulmonary sequelae, 5%-10% will develop severe COVID-19 pneumonia and acute respiratory distress syndrome (ARDS).
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