AI Article Synopsis
- A new strategy leverages galectin to target matrix metalloproteinases (MMPs) in cancer treatment.
- A bifunctional conjugate consisting of lactose and an MMP inhibitor can bind to both MMPs and Gal-3.
- This approach may enhance the effectiveness of the MMP inhibitor at tumor sites while simultaneously blocking the pro-tumoral activities of the galectin.
Article Abstract
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.
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| http://dx.doi.org/10.1002/chem.201203794 | DOI Listing |
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