A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815631 | PMC |
| http://dx.doi.org/10.1002/adma.201202881 | DOI Listing |
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