Chimeric polypeptides (CPs) that are derived from elastin-like polypeptides (ELPs) can self-assemble to form nanoparticles by site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone. Molecules with a distribution coefficient greater than 1.5 impart sufficient amphiphilicity to drive self-assembly into sub-100 nm nanoparticles.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801213 | PMC |
| http://dx.doi.org/10.1002/anie.201200899 | DOI Listing |
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