AI Article Synopsis

  • A series of anthra[1,2-d]imidazole-6,11-dione derivatives were created and tested for their ability to inhibit telomerase and reduce cancer cell growth in a lab setting.
  • Most compounds showed promising results in the screening process, with notable exceptions including compounds 4, 7, 16, 24, 27, and 28.
  • Compounds 16, 39, and 40 specifically reduced hTERT expression without significantly impacting overall cell growth, indicating a potential for targeted cancer treatment strategies.

Article Abstract

A series of anthra[1,2-d]imidazole-6,11-dione derivatives were synthesized and evaluated for telomerase inhibition, hTERT expression and suppression of cancer cell growth in vitro. All of the compounds tested, except for compounds 4, 7, 16, 24, 27 and 28 were selected by the NCI screening system. Among them, compounds 16, 39, and 40 repressed hTERT expression without greatly affecting cell growth, suggesting for the selectivity toward hTERT expression. Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase and polypharmacological targeting strategy.

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http://dx.doi.org/10.1016/j.ejmech.2012.11.032DOI Listing

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