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Biglycan stimulates retinal pathological angiogenesis via up-regulation of CXCL12 expression in pericytes.
FASEB J
January 2025
Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Retinal pathological angiogenesis (PA) is a common hallmark in proliferative retinopathies, including age-related macular degeneration (AMD), proliferative diabetic retinopathy (PDR), and retinopathy of prematurity (ROP). The mechanisms underlying PA is complex and incompletely understood. In this study, we investigated the role of extracellular matrix (ECM) protein biglycan (BGN) in PA using an oxygen-induced retinopathy (OIR) mouse model, along with hypoxia (1% O) conditions for incubating pericytes and endothelial cells in vitro.
View Article and Find Full Text PDFTree Lifespans in a Warming World: Unravelling the Universal Trade-Off Between Growth and Lifespan in Temperate Forests.
Glob Chang Biol
January 2025
State Key Laboratory of Efficient Production of Forest Resources, Beijing Forestry University, Beijing, China.
Tree growth and lifespan are key determinants of forest dynamics, and ultimately control carbon stocks. Warming and increasing CO have been observed to increase growth but such increases may not result in large net biomass gains due to trade-offs between growth and lifespan. A deeper understanding of the nature of the trade-off and its potential spatial variation is crucial to improve predictions of the future carbon sink.
View Article and Find Full Text PDFImmediate Pre-Endodontic Dentin Sealing (IPDS) Improves Resin-Dentin Bond Strength.
J Esthet Restor Dent
January 2025
Magne Education, Beverly Hills, California, USA.
Objective: Chemicals used during canal disinfection and endodontic sealers have a deleterious effect on dentin bond strength. The aim of this study was to evaluate a novel clinical sequence to improve the resin-dentin microtensile bond strength (μTBS) to endodontically treated teeth.
Materials And Methods: Twenty human molars were distributed in four experimental groups (n = 5, N = 20): C-control group without exposure to any endodontic chemical substances (2.
Reduced expression of the serotonin transporter impacts mitochondria in a sexually dimorphic manner.
Biochem Biophys Rep
March 2025
School of Biological Sciences, Victoria University of Wellington Kelburn, Parade, 6012, Wellington, New Zealand.
Neuropsychiatric and neurodevelopmental disorders are complex conditions that arise from a variety of interacting genetic and environmental factors. Among these factors, altered serotonergic signalling and mitochondrial dysfunction are strongly implicated, with a growing body of evidence to suggesting that serotonergic signalling is an important regulator of mitochondrial biogenesis. The serotonin transporter (SERT) functions to regulate synaptic 5-HT, and human allelic variants of the serotonin reuptake transporter-linked polymorphic region (5-HTTLPR) are associated with reduced SERT expression and increased susceptibility for developing neuropsychiatric disorders.
View Article and Find Full Text PDFStructure/function of ATP sulfurylase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthase (hPAPSS).
Biochem Biophys Rep
March 2025
College of Biomedical Sciences, Larkin University, Miami, FL, 33169, USA.
3'-phosphoadenosine 5'-phosphosulfate (PAPS) is synthesized by PAPS synthase (PAPSS) in two steps. In the first step ATP sulfurylase (ATPS) transfers sulfate group onto adenylyl moiety of ATP to form adenosine 5'-phosphosulfate (APS) and PPi. APS-kinase (APSK) then transfers the gamma-phosphoryl from ATP onto 3'-OH of APS to form PAPS and ADP.
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