Modular networks of delay-coupled and pulse-coupled oscillators are presented, which display both transient (metastable) synchronization dynamics and the formation of a large number of "chimera" states characterized by coexistent synchronized and desynchronized subsystems. We consider networks based on both community and small-world topologies. It is shown through simulation that the metastable behaviour of the system is dependent in all cases on connection delay, and a critical region is found that maximizes indices of both metastability and the prevalence of chimera states. We show dependence of phase coherence in synchronous oscillation on the level and strength of external connectivity between communities, and demonstrate that synchronization dynamics are dependent on the modular structure of the network. The long-term behaviour of the system is considered and the relevance of the model briefly discussed with emphasis on biological and neurobiological systems.
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http://dx.doi.org/10.1063/1.4766592 | DOI Listing |
J Am Chem Soc
January 2025
New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
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January 2025
Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Osteosarcoma (OS) is the most common bone malignancy. c-MET is recognized as a therapeutic target. However, traditional c-MET inhibitors show compromised efficacy due to the acquired resistance and side effects.
View Article and Find Full Text PDFJ Med Chem
December 2024
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Rearranged during transfection (RET) kinase is a validated therapeutic target for various cancers characterized by RET alterations. Although two selective RET inhibitors, selpercatinib and pralsetinib, have been approved by the FDA, acquired resistance through solvent-front mutations has been identified rapidly. Developing proteolysis targeting chimera (PROTAC) targeting RET mutations offers a promising strategy to combat drug resistance.
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School of Biological Sciences, Southern Illinois University, Carbondale, IL, USA.
Comp Biochem Physiol B Biochem Mol Biol
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State Key Laboratory of Mariculture Breeding, Fisheries College, Jimei University, Xiamen 361021, China. Electronic address:
Toll-like receptor 5 (TLR5) plays a crucial role in the immune response through recognizing bacterial flagellin. Some teleosts possess two forms of TLR5, including a canonical membrane TLR5 (TLR5M) ortholog and a piscine soluble TLR5 (TLR5S). In this report, the full-length cDNA sequences of Larimichthys crocea TLR5M (LcTLR5M) and TLR5S (LcTLR5S) were identified.
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