Two-photon polymerization has developed as a powerful tool for making micro- and nanoscale structures for regenerative medicine applications. This review discusses micro- and nanoscale aspects of tissue engineering, which are followed by a brief description of the two-photon polymerization process and how it has been used thus far in tissue engineering and other regenerative medicine applications. Lastly, potential future applications of two-photon polymerization in regenerative medicine are presented. This review provides a comprehensive summary of the uses of two-photon polymerization thus far in regenerative medicine and a look into how this technique will be used in the future.
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http://dx.doi.org/10.2741/e642 | DOI Listing |
Lab Chip
January 2025
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza L. da Vinci, 32, 20133 Milan, Italy.
The process of angiogenesis plays a pivotal role in skin regeneration, ensuring the provision of nutrients and oxygen to the nascent tissue, thanks to the formation of novel microvascular networks supporting functional tissue regeneration. Unfortunately, most of the current therapeutic approaches for skin regeneration lack vascularization, required to promote effective angiogenesis. Thus, tridimensional models, complemented with specific biochemical signals, can be a valuable tool to unravel the neovascularization mechanisms and develop novel clinical strategies.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Laser Thermal Laboratory, Department of Mechanical Engineering, University of California, Berkeley, California 94720, United States.
J Phys Chem Lett
December 2024
Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
Optical vortices possess a helical phase wavefront with central phase dislocation and orbital angular momentum. We demonstrated three-dimensional microstructure formation using a femtosecond optical vortex beam. Two-photon polymerization of photocurable resin was induced by long-term exposure, resulting in the fabrication of cylindrical structures.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Engineering Product Development, Singapore University of Technology and Design, Singapore, 487372, Singapore.
Spatially selective imaging (SSI) involves sampling a group of pixels from different positions on an encoded object to display a decoded image. Here, SSI is achieved by using off-axis cylindrical Fresnel lens arrays to decode multiple images from an encoded print of structural color pixels. Each image is optically retrieved by separately placing different "keys" (arrays of lenses in different pseudorandom configurations) over the same encoded print, and then each image is digitally reconstructed for visualization.
View Article and Find Full Text PDFNanoscale Adv
December 2024
Brussels Photonics (B-PHOT), Department of Applied Physics and Photonics, Vrije Universiteit Brussel and Flanders Make Pleinlaan 2 B-1050 Brussels Belgium
Surface-enhanced Raman spectroscopy (SERS) has shown its ability to characterize biological substances down to a single-molecule level without a specific biorecognition mechanism. Various nanofabrication technologies enable SERS substrate prototyping and mass manufacturing. This study reports a complete cycle of design, fabrication, prototyping, and metrology of SERS substrates based on two-photon polymerization (2PP).
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