AI Article Synopsis
- A 72-year-old woman experienced overlapping neurological conditions: Miller Fisher syndrome, Guillain-Barré syndrome, and Bickerstaff's brainstem encephalitis following an upper respiratory infection.
- Symptoms included double vision, unsteady walking, weakness in upper limbs, and altered consciousness, prompting diagnoses at different stages over several days.
- She received immunotherapy, fully recovered after ten months, and tested positive for specific antibodies, suggesting these syndromes may represent a related antibody-mediated process.
Article Abstract
We report a 72-year-old woman with overlapping Miller Fisher syndrome (MFS), Guillain-Barré syndrome (GBS) and Bickerstaff's brainstem encephalitis (BBE). She developed diplopia and unsteady gait a week after an upper respiratory infection on day 1. She had weakness of both upper limbs on day 3 and became drowsy, and her respiratory status worsened on day 5. Neurologic examination revealed ophthalmoplegia, ataxia, symmetrical weakness, areflexia, and consciousness disturbance. We diagnosed her with MFS on day 1, GBS on day 3 and overlapping BBE on day 5. She underwent immunoadsorption therapy and two courses of intravenous immunoglobulin therapy. Ten months after onset, her symptoms had fully recovered. Anti-GM1 IgG, GD1a IgG, GQ1b IgG, and GT1a IgG antibodies were positive. Our case supports the notion that MFS, GBS, and BBE are all part of a continuous clinical spectrum, which is an antibody-mediated process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531931 | PMC |
| http://dx.doi.org/10.1159/000345847 | DOI Listing |
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