AI Article Synopsis
- Recent studies have enhanced our understanding of the biology of thyroid cancers, particularly papillary and follicular types, but challenges remain in diagnosing their aggressiveness and managing advanced cancers.
- Thyroid cancers present diagnostic difficulties, especially in distinguishing between types of follicular lesions and determining appropriate treatments for more severe cases.
- Metallothioneins (MTs) play a role in cancer cell growth and resistance to certain treatments, suggesting they could be valuable in diagnosing and managing thyroid lesions.
Article Abstract
Recent findings in the past two decades have brought many insights into the biology of thyroid benign and malignant lesions, in particular the papillary and follicular thyroid cancers. Although, much progress have been made, thyroid cancers still pose diagnostic problems regarding differentiation of follicular lesions in relation to their aggressiveness and the treatment of advanced and undifferentiated thyroid cancers. Metallothioneins (MTs) were shown to induce cancer cells proliferation, mediate resistance to apoptosis, certain chemotherapeutics and radiotherapy. Therefore, MTs may be of utility in diagnosis and management of patients with benign and malignant lesions of the thyroid.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544669 | PMC |
| http://dx.doi.org/10.1186/1756-6614-5-26 | DOI Listing |
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