An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through a rational logical design, multifundamental reactions (iodination, Kornblum oxidation, and annulation) were assembled in one-pot. The developed approach can efficiently synthesize luntonin F and a diversity of analogues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol303331g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring Logical Intuition in Base-Rate Problems Using the Instructional Manipulation Paradigm.
Behav Sci (Basel)
January 2025
School of Psychology, Jiangxi Normal University, Nanchang 330022, China.
The default-interventionist model of dual-process theories proposes that stereotype descriptions in base-rate problems are processed using Type 1 processing, while the evaluation of base rates depends on Type 2 processing. The logical intuition view posits that people can process base-rate information using Type 1 processing. This study examined the logical intuition view using the instructional manipulation paradigm.
View Article and Find Full Text PDFLogic Circuits for Intelligent Microcystin Monitoring Based on Aptamer Recognition and Toehold-Mediated Hairpin DNA Self-Assembly.
Anal Chem
January 2025
Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China.
A sensitive fluorescence biosensor was developed for microcystin-LR (MC-LR) detection using H1, H2, and H3 DNA probes as sensing elements. The aptamer in H1 can recognize the target. H2 was labeled with FAM and BHQ.
View Article and Find Full Text PDFRational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.
ACS Nano
January 2025
School of Medicine, Nankai University, Tianjin 300071, China.
Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.
View Article and Find Full Text PDFThe Janus Effect: The Biochemical Logic of Antibiotic Resistance.
Biochemistry
January 2025
David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Antibiotics are essential medicines threatened by the emergence of resistance in all relevant bacterial pathogens. The engagement of the molecular targets of antibiotics offers multiple opportunities for resistance to emerge. Successful target engagement often requires passage of the antibiotic from outside into the cell interior through one or two distinct membrane barriers.
View Article and Find Full Text PDFAutonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells.
ACS Nano
January 2025
Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Article Synopsis
- Recent advancements in autonomous technology show promise for revolutionizing areas like nanomedicine by enabling efficient operation of biological therapies without human intervention.
- Engineering biological nanocomputing agents from nucleic acids and proteins presents challenges, despite two decades of research demonstrating their logical behavior within living cells.
- The paper discusses the programmability and synergy of nucleic acids and proteins, highlights their versatility in creating new functions, and addresses potential limitations in the field of nanocomputing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!