On the basis of the theory of specific long-range interaction between long molecules the approach has been elaborated for the "fast reading" of nucleotide sequences in sole DNA molecule. Firstly, a stretching force applies to the molecule that causes its unwinding from B-form to so called S-form. Then, a molecule disposes in a stretched state on the background. After this, the electrostatic potential is estimated in the space along the DNA filament. Information obtained is sufficient for the deduction of the nucleotide sequence in DNA. Another approach to the "reading" of information reduces to the measurement of the filament element deformation induced by electrostatic field from the electrode that stretches the filament by alternating current applied.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Evidence of Dirac Quantum Spin Liquid in YbZn_{2}GaO_{5}.
Phys Rev Lett
December 2024
Duke University, Department of Physics, Durham, North Carolina 27708, USA.
The emergence of a quantum spin liquid (QSL), a state of matter that can result when electron spins are highly correlated but do not become ordered, has been the subject of a considerable body of research in condensed matter physics [1,2]. Spin liquid states have been proposed as hosts for high-temperature superconductivity [3] and can host topological properties with potential applications in quantum information science [4]. The excitations of most quantum spin liquids are not conventional spin waves but rather quasiparticles known as spinons, whose existence is well established experimentally only in one-dimensional systems; the unambiguous experimental realization of QSL behavior in higher dimensions remains challenging.
View Article and Find Full Text PDFA subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.
Biol Open
January 2025
Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell fate decisions during cortical development sculpt the identity of long-range connections that subserve complex behaviors. These decisions are largely dictated by mutually exclusive transcription factors, including CTIP2/Bcl11b for subcerebral projection neurons and BRN1/Pou3f3 for intra-telencephalic projection neurons. We have recently reported that the balance of cortical CTIP2-expressing neurons is altered in a mouse model of DDX3X syndrome, a female-biased neurodevelopmental disorder associated with intellectual disability, autism spectrum disorder, and significant motor challenges.
View Article and Find Full Text PDFSource-specific bias correction of US background and anthropogenic ozone modeled in CMAQ.
Geosci Model Dev
November 2024
School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
United States (US) background ozone (O) is the counterfactual O that would exist with zero US anthropogenic emissions. Estimates of US background O typically come from chemical transport models (CTMs), but different models vary in their estimates of both background and total O. Here, a measurement-model data fusion approach is used to estimate CTM biases in US anthropogenic O and multiple US background O sources, including natural emissions, long-range international emissions, short-range international emissions from Canada and Mexico, and stratospheric O.
View Article and Find Full Text PDFEpstein-Barr virus (EBV) contributes to ~1.5% of human cancers, including lymphomas, gastric and nasopharyngeal carcinomas. In most of these, nearly 80 viral lytic genes are silenced by incompletely understood epigenetic mechanisms, precluding use of antiviral agents such as ganciclovir to treat the 200,000 EBV-associated cancers/year.
View Article and Find Full Text PDFWildPose: A long-range 3D wildlife motion capture system.
J Exp Biol
January 2025
African Robotics Unit, University of Cape Town, Cape Town, 7700, Western Cape, South Africa.
Understanding and monitoring wildlife behavior is crucial in ecology and biomechanics, yet challenging due to the limitations of current methods. To address this issue, we introduce WildPose, a novel long-range motion capture system specifically tailored for free-ranging wildlife observation. This system combines an electronically controllable zoom-lens camera with a LiDAR to capture both 2D videos and 3D point cloud data, thereby allowing researchers to observe high-fidelity animal morphometrics, behavior and interactions in a completely remote manner.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!