AI Article Synopsis
- The study focused on the effects of obesity and cerebral hypoperfusion on cognitive performance in older adults with heart failure (HF).
- A sample of 99 HF patients was assessed using neuropsychological tests and measurements of cerebral blood flow, revealing that lower blood flow and higher body mass index (BMI) correlated with poor cognitive function.
- The findings highlight that the combination of low cerebral perfusion and high BMI significantly worsens attention and executive function, suggesting that managing weight could be beneficial for HF patients at risk for cognitive decline.
Article Abstract
Background: Cerebral hypoperfusion accompanies heart failure (HF) and is associated with reduced cognitive performance. Obesity is prevalent in persons with HF and is also a likely contributor to cognitive function, as it has been independently linked to cognitive impairment in healthy individuals. The current study examined the association between obesity and cognitive performance among older adults with HF and whether obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment.
Methods: Patients with HF (n = 99, 67.46 ± 11.36 years of age) completed neuropsychological testing and impedance cardiography. Cerebral blood flow velocity (CBF-V) measured by transcranial Doppler sonography quantified cerebral perfusion and body mass index (BMI) operationalized obesity.
Results: A hierarchical regression analysis showed that lower CBF-V was associated with reduced performance on tests of attention/executive function and memory. Elevated BMI was independently associated with reduced attention/executive function and language test performance. Notably, a significant interaction between CBF-V and BMI indicated that a combination of hypoperfusion and high BMI has an especially adverse influence on attention/executive function in HF patients.
Conclusions: The current findings suggest that cerebral hypoperfusion and obesity interact to impair cognitive performance in persons with HF. These results may have important clinical implications, as HF patients who are at high risk for cerebral hypoperfusion may benefit from weight reduction.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507266 | PMC |
| http://dx.doi.org/10.1159/000343222 | DOI Listing |
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