A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent (68)Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526150 | PMC |
| http://dx.doi.org/10.2147/IJN.S38107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microwave-Assisted Extraction of Cellulose from Aloe Vera Plant Residue and Preparation of Cellulose Nanocrystal-Poly(vinyl alcohol) Hydrogels.
Molecules
December 2024
Department of Material Science and Engineering, University of Ioannina, 45110 Ioannina, Greece.
Biomass valorization and bio-based material development are of major research interest following the spirit of the circular economy. Aloe vera cultivation is a widespread agricultural activity oriented toward supplement production because of its well-known antioxidant and antimicrobial properties. Aloe vera juice production also produces a large amount of biomass byproducts that are usually landfilled.
View Article and Find Full Text PDFNanocomposites Based on Iron Oxide and Carbonaceous Nanoparticles: From Synthesis to Their Biomedical Applications.
Materials (Basel)
December 2024
National Institute of Materials Physics, Atomistilor Street, No 405 A, 077125 Magurele, Romania.
Nanocomposites based on FeO and carbonaceous nanoparticles (CNPs), including carbon nanotubes (CNTs) and graphene derivatives (graphene oxide (GO) and reduced graphene oxide (RGO)), such as FeO@GO, FeO@RGO, and FeO@CNT, have demonstrated considerable potential in a number of health applications, including tissue regeneration and innovative cancer treatments such as hyperthermia (HT). This is due to their ability to transport drugs and generate localized heat under the influence of an alternating magnetic field on FeO. Despite the promising potential of CNTs and graphene derivatives as drug delivery systems, their use in biological applications is hindered by challenges related to dispersion in physiological media and particle agglomeration.
View Article and Find Full Text PDFBiomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement.
Int J Mol Sci
December 2024
Biotechnology Center, The Silesian University of Technology, 44-100 Gliwice, Poland.
Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and the associated risks of post-surgical complications for patients. Traditional bone implants, like allografts, and autografts, have limitations, such as donor site morbidity and potential patient inflammation. Over two million bone transplant procedures are performed yearly, and success varies depending on the material used.
View Article and Find Full Text PDFRecent developments in alginate-based nanocomposite coatings and films for biodegradable food packaging applications.
Int J Biol Macromol
January 2025
Department of Chemical Engineering, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates; Food Security and Technology Center, Khalifa University of Science and Technology, P. O. Box 127788, Abu Dhabi, United Arab Emirates. Electronic address:
Packaging made of plastic harms the environment. Thus, polysaccharide edible films are becoming a popular food packaging solution. Alginate is a biopolymer derived from seaweed that has the potential to create food packaging materials that are environmentally friendly and biodegradable.
View Article and Find Full Text PDFEnhancement of polycaprolactone nanofiber film performance by hydrogen bonding interactions with chitosan for food packaging.
Int J Biol Macromol
January 2025
Department of Food Science and Technology, Sunchon National University, Suncheon, Jeonnam 57922, Republic of Korea; Bio-Healthcare Research and Analysis Center, Sunchon National University, Suncheon, Jeonnam 57922, Republic of Korea; Glocal University Project Team, Sunchon National University, 255 Jungangno, Suncheon 57922, Jeonnam, Republic of Korea. Electronic address:
Hybrid environmentally friendly nanocomposite films were synthesized via electrospinning using polycaprolactone (PCL) and chitosan (CH). The resulting nanofiber films displayed a homogeneous fibrous microstructure with average diameters between 250-270 nm. Molecular simulation experiments revealed a progressive increase in hydrogen bonding over time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!