Colonization of the oropharynx by Kingella kingae is currently considered to be a prerequisite for later development of invasive infections. However, the oropharyngeal K. kingae DNA bacterial load in children with osteoarticular infections caused by this microorganism is not different than that of asymptomatic carriers.
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http://dx.doi.org/10.1097/INF.0b013e3182846e8f | DOI Listing |
Front Pediatr
January 2025
Pediatric Orthopedic Unit, Pediatric Surgery Service, Geneva University Hospitals, Geneva, Switzerland.
In recent years, advancements in modern laboratory diagnostics have identified () as the major cause of osteoarticular infections in early childhood. The introduction of novel diagnostic methods has ushered in a new era, transitioning from underrated infections to recognizing as the primary etiology of skeletal system infections in children. This article provides a new perspective on , exploring innovative diagnostic methods that have improved and will continue to transform the management of these infections.
View Article and Find Full Text PDFJ Child Orthop
January 2025
Great Ormond St Hospital for Children, London, UK.
Biochimie
December 2024
Institute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20, Prague, Czech Republic. Electronic address:
Kingella kingae, an emerging pediatric pathogen, secretes the pore-forming toxin RtxA, which has been implicated in the development of various invasive infections. RtxA is synthesized as a protoxin (proRtxA), which gains its biological activity by fatty acylation of two lysine residues (K558 and K689) by the acyltransferase RtxC. The low acylation level of RtxA at K558 (2-23 %) suggests that the complete acylation at K689 is crucial for toxin activity.
View Article and Find Full Text PDFJ Bone Joint Surg Am
December 2024
Pediatric Orthopaedic Unit, Pediatric Surgery Service, Geneva University Hospitals, Geneva, Switzerland.
Background: Transphyseal hematogenous osteomyelitis (THO) is a common infectious condition, being present in 25% of patients with hematogenous osteomyelitis. A large proportion of pediatric hematogenous osteomyelitis infections can spread through the growth cartilage and therefore may be potentially responsible for growth disorders, leading to limb-length discrepancy or angular deformities. The purpose of the present study was to identify both the prevalence of complications caused by transphyseal osteomyelitis and factors influencing their occurrence.
View Article and Find Full Text PDFCurr Rev Musculoskelet Med
December 2024
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
Purpose Of Review: For pediatric osteomyelitis and septic arthritis, 10-24% of cases occur in the upper extremity (UE). Due to delays in presentation and diagnosis, UE infections are often more complex and severe than infections of the lower extremity (LE). This review evaluates the literature from the past 6 years related to pediatric osteomyelitis and septic arthritis of the UE and provides a guide for professionals managing these conditions in children.
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