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The severity of COVID 19 symptoms has a direct correlation with lymphopenia, affecting natural killer (NK) cells. SARS-CoV-2 specific "memory" NK cells obtained from convalescent donors can be used as cell immunotherapy. In 2022 a phase I, dose-escalation, single center clinical trial was conducted to evaluate the safety and feasibility of the infusion of CD3/CD56 NK cells against moderate/severe cases of COVID-19 (NCT04578210).
View Article and Find Full Text PDFThe IL-23/Th17 pathway inhibitors in the treatment of psoriasis and the risk of skin malignancies: a review.
Postepy Dermatol Alergol
December 2024
Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland.
Psoriasis and psoriatic arthritis are chronic inflammatory conditions that constitute a significant global health burden due to their prevalence and impact on quality of life. A deeper comprehension of psoriasis and psoriatic arthritis pathogenesis has recently led to the emergence of novel classes of biologics targeting the IL-23/Th17 pathway. The specific role of interleukin-12, -23, and -17 in cancer as either promoters or inhibitors is under investigation in various studies.
View Article and Find Full Text PDFBrain drain in Emergency Medicine in Lebanon, building locally and exporting globally.
BMC Med Educ
January 2025
Department of Emergency Medicine, American University of Beirut, P.O.Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon.
Objective: Despite the growth of Emergency Medicine (EM) globally, shortages of EM-trained physicians persist in many countries, disproportionately affecting lower middle/low-income countries (LMIC/LIC). This study examines the career paths of graduates of an Emergency Medicine residency-training program established in Lebanon with the aim of building local capacity in EM.
Design And Patients: This descriptive study utilizes secondary data sourced from an alumni database that includes nine cohorts of graduates from an Emergency Medicine residency program at the American University of Beirut Medical Center in Lebanon.
Retrospective cohort study of trends in the use of outpatient parathyroidectomy by surgical indication.
Surgery
January 2025
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; Center for Surgery and Health Economics, Department of Surgery, University of Pennsylvania, Philadelphia, PA; Leonard David Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Division of Endocrine and Oncologic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
Background: A shift toward outpatient parathyroidectomy was seen in the early 2000s. Recent trends, especially for secondary and tertiary hyperparathyroidism, have not been described. This study evaluates temporal trends in same-day, overnight, and inpatient parathyroidectomy by surgical indication.
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