Objective: To examine relationships among daily activity levels, body composition and bone outcomes in children aged 6.7 years who were born at term with birth weights <20th centile.
Methods: Activity data collected using accelerometers were correlated with body composition and bone outcome z-scores from dual-energy X-ray absorptiometry in 36 children.
Results: Activity levels were related to body composition outcomes; for example, lean mass index (lean mass/height(2)) was positively associated with time spent in moderate activity (r=0.40, p=0.02) and negatively with time spent in sedentary activity (r=-0.50, p=0.002). Per cent time spent in sedentary activity correlated negatively with whole body bone mineral density z-score (r=-0.44, p=0.01) and hip bone mineral content (r=-0.38, p=0.03).
Conclusions: Moderate and vigorous activity levels were associated with increased lean and bone mass in this population but not with conventional measures of adiposity such as weight and body mass index z-scores. Standard measures of adiposity may mask potential benefits of regular activity.
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http://dx.doi.org/10.1136/archdischild-2012-302823 | DOI Listing |
J Physiol
January 2025
Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Eat Weight Disord
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Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Bull
January 2025
Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia.
Sarcopenic obesity (SO) is a body composition phenotype derived from the simultaneous presence in the same individual of an increase in fat mass and a decrease in skeletal muscle mass and/or function. Several protocols for the diagnosis of SO have been proposed in the last two decades making prevalence and disease risk estimates of SO heterogeneous and challenging to interpret. Dementia is a complex neurological disorder that significantly impacts patients, carers and healthcare systems.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Nutritional Sciences Graduate Program, Rutgers University, New Brunswick, New Jersey, United States; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States; Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, United States; Endocrinology and Animal Biosciences Graduate Program, Rutgers University, New Brunswick, New Jersey, United States; New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey, United States. Electronic address:
Amino acid starvation by the chemotherapy agent asparaginase is a potent activator of the integrated stress response (ISR) in liver and can upregulate autophagy in some cell types. We hypothesized that autophagy related 7 (ATG7), a protein that is essential for autophagy and an ISR target gene, was necessary during exposure to asparaginase to maintain liver health. We knocked down Atg7 systemically (Atg7) or in hepatocytes only (ls-Atg7KO) in mice before exposure to pegylated asparaginase for 5 d.
View Article and Find Full Text PDFJ Arthroplasty
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International Joint Center, Acibadem University Hospital, Istanbul, Turkey.
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