The study based on immunological and epidemiological evaluation of large groups of population has revealed the factors responsible principally for periodontitis pattern. They are: 1) microbial and tissue sensitization, 2) immune defences, 3) disturbed microcirculation in periodontal tissues. In view of various causes underlying periodontitis it is advisable to take them into consideration when evaluating diagnostic data and deciding on indications for immunocorrective therapy.
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