Synthesis of ¹³C-labeled and functionalized Hyaluronan derivatives for biophysical studies and surface modifications.

Bioorg Med Chem

Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.

Published: February 2013

A convergent synthesis of a tetrasaccharide partial sequence of (13)C-labeled Hyaluronan is presented. This tetrasaccharide can be used for biophysical studies as well as for surface modifications. Furthermore, tetrasaccharide 7 can be employed for the synthesis of additionally labeled higher oligomers of Hyaluronan on the basis of the presented methodology.

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http://dx.doi.org/10.1016/j.bmc.2012.11.025DOI Listing

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