AI Article Synopsis
- Salivary α-amylase (sAA) is a potential indicator of stress response linked to the sympathoadrenal medullary system; this study examines its levels in patients with obsessive-compulsive disorder (OCD) compared to healthy individuals.
- Findings show that OCD patients exhibited significantly higher scores for anxiety and depression while having lower vigor compared to healthy controls, but no differences were observed in heart rate variability (HRV) between the two groups.
- The research indicates that OCD patients had elevated sAA levels under stress, suggesting a heightened sensitivity to stressors, potentially marking a unique characteristic of OCD.
Article Abstract
Salivary α-amylase (sAA) serves as a marker of sympathoadrenal medullary system (SAM) activity. Salivary AA has not been extensively studied in obsessive-compulsive disorder (OCD) patients. In the current study, 45 OCD patients and 75 healthy volunteers were assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Profile of Mood State (POMS), and the State-Trait Anxiety Inventory (STAI). Measures of heart rate variability (HRV), sAA, and salivary cortisol were also obtained following the application of electrical stimulation stress. The Y-BOCS and POMS Tension-Anxiety, Depression-Dejection, Anger-Hostility, Fatigue, and Confusion scores were significantly increased in patients with OCD compared with healthy controls. In contrast, Vigor scores were significantly decreased in patients with OCD relative to scores in healthy controls. There was no difference in HRV between the patients and the controls. Salivary AA levels in female and male OCD patients were significantly elevated relative to controls both before and after electrical stimulation. In contrast, there were no differences in salivary cortisol levels between OCD patients and controls. The elevated secretion of sAA before and after stimulation may suggest an increased responsiveness to novel and uncontrollable situations in patients with OCD. An increase in sAA might be a characteristic change of OCD.
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| http://dx.doi.org/10.1016/j.psychres.2012.11.010 | DOI Listing |
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