An ionic liquid-based ultrasonic-assisted extraction (ILUAE) method had been used for the effective extraction of isoliquiritigenin (IQ), liquiritin (LQ) and glycyrrhizic acid (GA) from licorice. The ionic liquids with different cations and anions were investigated in this work and 0.5 M 1-butyl-3-methylimidazolium bromide solution was selected as solvent. In addition, the technical parameters including soaking time, solid-liquid ratio, ultrasonic power and time were optimized. Compared with the conventional solvent extraction, the proposed approach exhibited higher efficiency, which indicated the ILUAE was an efficient, rapid and simple sample preparation technique. There was no degradation of the target analytes had been observed at the optimum conditions which was evidenced by the stability studies performed with standard of IQ, LQ and GA. The proposed method also showed high reproducibility and was environmental friendly.
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http://dx.doi.org/10.1016/j.foodchem.2012.10.059 | DOI Listing |
Commun Biol
January 2025
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Rapid structural analysis of purified proteins and their complexes has become increasingly common thanks to key methodological advances in cryo-electron microscopy (cryo-EM) and associated data processing software packages. In contrast, analogous structural analysis in cells via cryo-electron tomography (cryo-ET) remains challenging due to critical technical bottlenecks, including low-throughput sample preparation and imaging, and laborious data processing methods. Here, we describe a rapid in situ cryo-ET sample preparation and data analysis workflow that results in the routine determination of sub-nm resolution ribosomal structures.
View Article and Find Full Text PDFSci Rep
January 2025
Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, 119991, Russia.
Vanadium dioxide ([Formula: see text]) is a favorable material platform of modern optoelectronics, since it manifests the reversible temperature-induced insulator-metal transition (IMT) with an abrupt and rapid changes in the conductivity and optical properties. It makes possible applications of such a phase-change material in the ultra-fast optoelectronics and terahertz (THz) technology. Despite the considerable interest to this material, data on its broadband electrodynamic response in different states are still missing in the literature.
View Article and Find Full Text PDFNurse Educ Today
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Lecturer in Nursing Education, Faculty of Nursing, Midwifery & Palliative Care, King's College London, 57 Waterloo Road, London, SE1 8WA. Electronic address:
Background/problems: Individuals with comorbid physical and mental health conditions face significant threats to their well-being while placing a substantial burden on healthcare systems through increased service costs. Nursing professionals encounter multiple challenges in delivering effective care to this population. These challenges include a lack of integrated care models, communication barriers among providers, the complexity of addressing dual health needs, insufficient training in comorbidity management, resource and time constraints, and pervasive stigma toward mental illness.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. Electronic address:
Asymmetrical flow field-flow fractionation (AF4) with multi-detection has continued to gain wider acceptance for characterizing complex drug products. An important quality attribute for these products is the measurement of the particle size distribution (PSD). Current limitations of established procedures (e.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2025
Institute of High Pressure Physics, School of Physical Science and Technology, Ningbo University, Ningbo, 315211, People's Republic of China, Ningbo, Zhejiang, 315211, CHINA.
The interactions between the carbon skeleton and the metal atoms of a binary transition metal carbide (BTMC) are particular interest for industrial applications with openning physics and chemitry questions, especially in magnetoelectric (ME) functional materials and cemented carbides. Chromium and carbon BTMCs are a series of intermetallic compounds with typical chemical formulas and sharepolycrystalline powder c somehromium special characteristics.and carbon as precursors, In this paper,and synthesized s we usedingle-phase bluk Cr7C3 (orthorhombic, with space group: Pnma) with high density and good crystallinity by means of high-temperature and high-pressure quenching method (HTHPQM).
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