AI Article Synopsis
- The study investigates the genetic variations in the prion protein gene (PRNP) across various Chinese indigenous goat breeds to understand their susceptibility or resistance to scrapie.
- Researchers found 10 polymorphic sites that resulted in 28 different haplotypes, with notable frequency differences between northern and southern goat breeds.
- The analysis suggests that northern and southern goat breeds may form distinct genetic clusters, which is important for developing effective strategies for selecting goats resistant to scrapie.
Article Abstract
Polymorphism of the prion protein gene (PRNP) is usually associated with scrapie susceptibility or resistance. To determine the variability of PRNP in Chinese indigenous goat breeds, we isolated genomic DNA from goat blood and amplified and sequenced the coding region of the gene. We identified 10 polymorphic sites that gave rise to 28 haplotypes. Clear frequency differences were found between northern and southern breeds and confirmed by genetic distance analysis, except for the Tangshan dairy goat. Phylogeographic analysis supported the idea that northern and southern breeds might be considered separate clusters, except for the Tangshan dairy goat. The finding of significant differences in allele distribution in northern and southern goats, especially if involved in modulating resistance/susceptibility, needs to be carefully considered for the feasibility of selection plans for resistance to scrapie.
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| http://dx.doi.org/10.1007/s10528-012-9556-7 | DOI Listing |
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