We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557967PMC
http://dx.doi.org/10.3201/eid1901.111527DOI Listing

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