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ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.
Mol Genet Genomic Med
March 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Background: The ABCG2 421C/A polymorphism contributes significantly to the distribution and absorption of antiretroviral (ARV) regimens and is associated with the undesirable side effects of efavirenz.
Methods: To investigate this, we examined ABCG2 34G/A (rs2231137) and 421C/A (rs2231142) genetic variations in 149 HIV-infected patients (116 without hepatotoxicity, 33 with ARV-induced hepatotoxicity) and 151 healthy controls through the PCR-restriction fragment length polymorphism (PCR-RFLP) technique.
Results And Discussion: The ABCG2 34GA genotype and 34A allele indicated a risk for antiretroviral therapy-associated hepatotoxicity development (p = 0.
High prevalence of low high-density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?
HIV Med
February 2024
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Background: Antiretroviral therapy-associated adverse effects and comorbidities are still pervasive in people living with HIV, especially metabolic syndrome (MetS). We investigated the age-dependent prevalence of components of MetS and insulin resistance in children and adolescents living with HIV (CALWH).
Methods: A cross-sectional pilot study of CALWH treated at the Baylor Uganda Clinical Centre of Excellence in Kampala, Uganda, May to August 2021.
Highly Active Antiretroviral Therapy-associated Lipodystrophy: Pseudo-Cushing's Syndrome.
J Assoc Physicians India
February 2023
Professor, Department of Endocrinology and Metabolism, Madurai Medical College and Government Rajaji Hospital, Madurai, Tamil Nadu, India.
Updates on HIV and Kidney Disease.
Curr HIV/AIDS Rep
April 2023
Department of Medicine, Division of Nephrology, Johns Hopkins University, 1830 E. Monument Street, Suite 416, Baltimore, MD, 21218, USA.
Purpose Of Review: With the advent of antiretroviral therapy, HIV infection has become a chronic disease in developed countries.
Recent Findings: Non-HIV-driven risk factors for kidney disease, such as APOL1 risk variants and other genetic and environmental factors, have been discovered and are better described. Consequently, the field of HIV-associated kidney disease has evolved with greater attention given to traditional risk factors of CKD and antiretroviral treatment's nephrotoxicity.
Abacavir causes leukocyte/platelet crosstalk by activating neutrophil P2X7 receptors thus releasing soluble lectin-like oxidized low-density lipoprotein receptor-1.
Br J Pharmacol
June 2023
Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain.
Background And Purpose: Abacavir, an antiretroviral drug used in HIV therapy associated with myocardial infarction, promotes thrombosis through P2X7 receptors. The role of platelets as pro-thrombotic cells is acknowledged whereas that of neutrophils-due to their secretory capacity-is gaining recognition. This study analyses the role of neutrophils-specifically the secretome of abacavir-treated neutrophils (SN )-in platelet activation that precedes thrombosis.
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