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INSERM, UMRS-839, Institut du Fer à Moulin, 17 rue du Fer à Moulin, 75005 Paris, France.
Published: December 2012
AI Article Synopsis
Neurons use a structure called the centrosome to help them move by creating microtubules, which guide their organelles.
The mother centriole in neurons forms a small stick-like part called a primary cilium, which helps send signals to the rest of the cell.
A signal called Sonic hedgehog (Shh) helps these neurons move away from their original paths, while blocking Shh keeps them in place.
Article Abstract
In migrating neurons, the centrosome nucleates and anchors a polarized network of microtubules that directs organelle movements. We report here that the mother centriole of neurons migrating tangentially from the medial ganglionic eminence (MGE) assembles a short primary cilium and exposes this cilium to the cell surface by docking to the plasma membrane in the leading process. Primary cilia are built by intraflagellar transport (IFT), which is also required for Sonic hedgehog (Shh) signal transduction in vertebrates. We show that Shh pathway perturbations influenced the leading process morphology and dynamics of MGE cells. Whereas Shh favored the exit of MGE cells away from their tangential migratory paths in the developing cortex, cyclopamine or invalidation of IFT genes maintained MGE cells in the tangential paths. Our findings show that signals transmitted through the primary cilium promote the escape of future GABAergic interneurons from their tangential routes to colonize the cortical plate.
