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Introduction: Vital dyes lymphography during laparoscopic varicocelectomy (LV) has been suggested to allow for lymphatic mapping thereby allowing for lymphatic sparing (LS) and subsequent reduction of hydrocele formation. Intratesticular injection of the dye seems to achieve the best lymphatic visualization, however, the potential toxicity of some agents, is a cause of concern for the risk of testicular pathological changes. We report our experience with LV, to test the hypothesis that Intraoperative lymphography with methylene blue (BL), is safe and reduces the rate of post-operative hydrocelectomy.

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Involvement of autophagy in germ cells in an experimental model of varicocele in rats before and after varicocelectomy.

Pediatr Surg Int

December 2024

Unit of Pediatric Surgery, Department of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, 98121, Messina, Italy.

Introduction: Autophagy, a catabolic process enabling cellular organelles and proteins' reuse for energy, has been observed in varicocele models, but the effect of surgical treatment on this process remains unknown. This study aims to assess autophagy in varicocele models undergoing surgical correction.

Materials And Methods: Twenty-one adolescent male rats were induced with varicocele and divided into three groups: sham, varicocele, and varicocele with varicocelectomy.

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Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions.

Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed.

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Background: A varicocele is an abnormal dilation of the pampiniform plexus of veins in the scrotum that commonly affects postpubertal males. The condition has been associated with male infertility, testicular hypotrophy, and pain. However, the clinical experiences of adolescent patients and their families regarding the evaluation, surveillance, and management of varicoceles have not been previously examined.

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Article Synopsis
  • Varicocele affects up to 15% of men and is linked to infertility; various surgical and radiological methods exist for treatment, but their effectiveness is uncertain.
  • A study comparing the Ivanissevich surgical technique and sclerotherapy in 94 patients found that sclerotherapy significantly improved sperm concentration, while surgical treatment reduced the number of patients with oligozoospermia.
  • Overall, the study did not determine a clear advantage of one method over the other but highlighted the importance of considering sperm bio-functional parameters in future research.
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