AI Article Synopsis
- α-Adrenoceptors play a crucial role in mediating interactions between the sympathetic nervous system and noradrenergic neurons, influencing the release of norepinephrine and other neurotransmitters.
- There are two main classes of α-adrenoceptors, α(1) and α(2), each with three subtypes that have specific functions and characteristics.
- The text outlines laboratory methods for studying α-adrenoceptors using isolated tissues and provides protocols for exploring the different subtypes of these receptors.
Article Abstract
α-Adrenoceptors mediate responses to activation of both peripheral sympathetic nerves and central noradrenergic neurons. They also serve as autoreceptors that modulate the release of norepinephrine (NE) and other neurotransmitters. There are two major classes of α-adrenoceptors, the α(1)- and α(2). Each class is subdivided into three subtypes: α(1A), α(1B), α(1D), and α(2A), α(2B), α(2C). Described in this unit are in vitro isolated tissue methods used to study α-adrenoceptor functions and to identify novel ligands for these receptors. Detailed protocols describing use of isolated tissues to study the various α(1)- and α(2)-adrenoceptor subtypes are provided.
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| http://dx.doi.org/10.1002/0471141755.ph0405s59 | DOI Listing |
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