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Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications.
Metabolites
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Molecular Microbiology and Structural Biochemistry, UMR 5086, CNRS, University Lyon, F-69367 Lyon, France.
Phosphatases are enzymes that catalyze the hydrolysis of phosphate esters. They play critical roles in diverse biological processes such as extracellular nucleotide homeostasis, transport of molecules across membranes, intracellular signaling pathways, or vertebrate mineralization. Among them, tissue-nonspecific alkaline phosphatase (TNAP) is today increasingly studied, due to its ubiquitous expression and its ability to dephosphorylate a very broad range of substrates and participate in several different biological functions.
View Article and Find Full Text PDFHindguts of harbor phylogenetically and genomically distinct capable of degrading algal polysaccharides and diazotrophy.
mSystems
December 2024
School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
The genus () is most often associated with human clinical samples and livestock. However, are also prevalent in the hindgut of the marine herbivorous fish (Silver Drummer), and analysis of their carbohydrate-active enzyme (CAZyme) encoding gene repertoires suggests degrade macroalgal biomass to support fish nutrition. To further explore host-associated traits unique to -derived , we compared 445 high-quality genomes of available in public databases (e.
View Article and Find Full Text PDFAlterations of upper-extremity functional muscle networks in chronic stroke survivors.
Exp Brain Res
December 2024
School of Biomedical sciences, University of Leeds, Leeds, UK.
Current clinical assessment tools don't fully capture the genuine neural deficits experienced by chronic stroke survivors and, consequently, they don't fully explain motor function throughout everyday life. Towards addressing this problem, here we aimed to characterise post-stroke alterations in upper-limb control from a novel perspective to the muscle synergy by applying, for the first time, a computational approach that quantifies diverse types of functional muscle interactions (i.e.
View Article and Find Full Text PDFAntiBody Sequence Database.
NAR Genom Bioinform
December 2024
Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, 28 rue du Dr Roux, F-75015 Paris, France.
Antibodies play a crucial role in the humoral immune response against health threats, such as viral infections. Although the theoretical number of human immunoglobulins is well over a trillion, the total number of unique antibody protein sequences accessible in databases is much lower than the number found in a single individual. Training AI (Artificial Intelligence) models, for example to assist in developing serodiagnoses or antibody-based therapies, requires building datasets according to strict criteria to include as many standardized antibody sequences as possible.
View Article and Find Full Text PDFDeveloping a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network.
Front Immunol
December 2024
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Background: Adults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to the immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected. However, there has been insufficient work to pinpoint where these risks concentrate within the immunosuppressed spectrum; surveillance efforts typically treat the immunosuppressed as a single entity, leading to wide confidence intervals.
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