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Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?
J Pharmacokinet Pharmacodyn
January 2025
Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
P-glycoprotein (P-gp) is a key efflux transporter and may be involved in drug-drug interactions (DDIs) at the blood-brain barrier (BBB), which could lead to changes in central nervous system (CNS) drug exposure. Morphine is a P-gp substrate and therefore a potential victim drug for P-gp mediated DDIs. It is however unclear if P-gp inhibitors can induce clinically relevant changes in morphine CNS exposure.
View Article and Find Full Text PDFRadio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma.
CNS Oncol
December 2024
UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision & Imaging Biomarkers, University of California Los Angeles, Los Angeles, CA 90024, USA.
A radio-pathomic machine learning (ML) model has been developed to estimate tumor cell density, cytoplasm density (Cyt) and extracellular fluid density (ECF) from multimodal MR images and autopsy pathology. In this multicenter study, we implemented this model to test its ability to predict survival in patients with recurrent glioblastoma (rGBM) treated with chemotherapy. Pre- and post-contrast T-weighted, FLAIR and ADC images were used to generate radio-pathomic maps for 51 patients with longitudinal pre- and post-treatment scans.
View Article and Find Full Text PDFA reduction in self-reported confidence accompanies the recall of memories distorted by prototypes.
Commun Psychol
July 2024
Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
When we recall a past event, we reconstruct the event based on a combination of episodic details and semantic knowledge (e.g., prototypes).
View Article and Find Full Text PDFBackground: Increases in GPNMB are detectable in FTD- cerebrospinal fluid (CSF) and post-mortem brain, and brains of aged -deficient mice. Although no upregulation of GPNMB is observed in the brains of young -deficient mice, peripheral immune cells of these mice do exhibit this increase in GPNMB. Importantly, the functional significance of GPNMB upregulation in progranulin-deficient states is currently unknown.
View Article and Find Full Text PDFPharmacodynamic, pharmacokinetic and rat brain receptor occupancy profile of NLX-112, a highly selective 5-HT receptor biased agonist.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Neurolixis SAS, 2 Rue Georges Charpak, 81100, Castres, France.
NLX-112 (i.e., F13640, befiradol) exhibits nanomolar affinity, exceptional selectivity and full agonist efficacy at serotonin 5-HT receptors.
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