Hospitals and health systems should undertake the following steps in pinpointing areas for clinical cost reduction: Identify potential areas of opportunity through an analysis of top discharges. Use severity-adjusted data to review variability by case. Review length of stay and resource consumption at a high level. Examine granular charge data and practice patterns. Determine action steps for improvement.
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Sci Rep
January 2025
Guizhou Mining Safety Science Research Institute Co., Ltd, Guiyang, 550025, China.
To enhance the safety of coal mining operations and improve the efficiency of gas extraction, hydraulic flushing technology has been widely used in low permeability coal seams. This study aims to investigate the mechanism of hydraulic flushing by conducting experiments focusing on four aspects: sample strength, punching pressure, punching position and vibration direction. The results show that an increase in hydraulic flushing pressure leads to a deeper impact groove, whereas higher sample strength results in a shallower groove.
View Article and Find Full Text PDFMicroorganisms
January 2025
Graduate Institute of Human Resource and Knowledge Management, National Kaohsiung Normal University, Kaohsiung 802561, Taiwan.
Vancomycin-intermediate (VISA) is a multi-drug-resistant pathogen of significant clinical concern. Various strains can cause infections, from skin and soft tissue infections to life-threatening conditions such as bacteremia and pneumonia. VISA infections, particularly bacteremia, are associated with high mortality rates, with 34% of patients succumbing within 30 days.
View Article and Find Full Text PDFAntibodies (Basel)
December 2024
Eli Lilly and Company, Lilly Corporate Center Indianapolis, Indianapolis, IN 46285, USA.
Background: The prediction of human clearance (CL) and subcutaneous (SC) bioavailability is a critical aspect of monoclonal antibody (mAb) selection for clinical development. While monkeys are a well-accepted model for predicting human CL, other preclinical species have been less-thoroughly explored. Unlike CL, predicting the bioavailability of SC administered mAbs in humans remains challenging as contributing factors are not well understood, and preclinical models have not been systematically evaluated.
View Article and Find Full Text PDFJ Radiol Prot
January 2025
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, AUSTRALIA.
Historically, radiation exposure to mineral sands workers arose primarily from intake of thorium associated with monazite dust generated in mineral separation plants. Research investigations in the 1990s provided greater insight into the characteristics of inhaled thorium ore dust and bioassay studies inferred that some workers had accumulated significant lung burdens of thorium. Recent changes to biokinetic models have increased the radiation dose assessed to arise from thorium intake, raising questions on the appropriateness of current assumptions used in exposure assessment and feasibility of further bioassay research.
View Article and Find Full Text PDFSci Rep
January 2025
School of Urban Planning and Municipal Engineering, Xi'an Polytechnic University, Xi'an, 710048, China.
With the increase in coal mining depths, soft and fractured roadway surrounding rocks require grouting and a sprayed protective layer for maintenance. Simultaneously, extensive accumulation of coal gangue causes diverse environmental issues. To enhance on-site coal gangue utilization, this study replaced river sand and cement with coal gangue to develop a novel cement-based mortar for supporting coal mine roadways.
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