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Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.
Elife
January 2025
Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether sensory experience affects dendritic morphology, we use the arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals.
View Article and Find Full Text PDFDifferences of longitudinal plasma biomarkers between single memory domain and multidomain subject cognitive decline: Evidence from SILCODE.
J Alzheimers Dis
January 2025
Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Background: Plasma biomarkers demonstrated potential in identifying amyloid pathology in early Alzheimer's disease. Different subtypes of subjective cognitive decline (SCD) may lead to different cognitive impairment conversion risks.
Objective: To investigate the differences of plasma biomarkers in SCD subtypes individuals, which were unclear.
Body composition differences in older adults with and without Alzheimer's disease: A systematic review and meta-analysis of observational studies.
J Alzheimers Dis
January 2025
Department of Medical Sciences, Minas Gerais State University, Minas Gerais, Brazil.
Background: Research on body composition and fat distribution in Alzheimer's disease (AD) has presented conflicting findings.
Objective: Compare body composition and anthropometric measurements in older adults with and without AD.
Methods: A systematic review and meta-analysis were conducted following Cochrane guidelines and PRISMA standards.
Fluid Management in Critical Care: New Insights Into Optimal Fluid Therapy.
Cureus
December 2024
Critical Care Medicine, Star Care Multispeciality Hospital, Kozhikode, IND.
Background: Fluid management is a crucial critical care component, influencing outcomes such as organ function, renal integrity, and survival in critically ill patients. Recent evidence suggests that balanced crystalloids may offer advantages over isotonic saline, particularly in reducing the risk of acute kidney injury (AKI) and other complications. This study aimed to evaluate the impact of balanced crystalloids versus isotonic saline on clinical outcomes in the intensive care unit (ICU), focusing on AKI, renal replacement therapy (RRT), and mortality.
View Article and Find Full Text PDFBridging the Gap: The Importance of Non-technical Skills in Cardiology for Enhanced Patient Care and Team Performance.
Cureus
December 2024
Acute Medicine, Portsmouth Hospitals University NHS Trust, Portsmouth, GBR.
Cardiology, a high-acuity medical specialty, has traditionally emphasised technical expertise, often overshadowing the critical role of non-technical skills (NTS). This imbalance stems from the historical focus on procedural competence and clinical knowledge in cardiology training and practice, leaving a significant gap in the development of crucial interpersonal and cognitive abilities. However, emerging evidence highlights the significant impact of NTS on patient outcomes, team dynamics, and overall healthcare efficiency.
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