A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600423 | PMC |
| http://dx.doi.org/10.1021/ol303003g | DOI Listing |
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