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Article Abstract
Objectives: Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury.
Materials And Methods: An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells.
Results: The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution.
Discussion: Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523530 | PMC |
| http://dx.doi.org/10.4103/0975-7406.103272 | DOI Listing |
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