AI Article Synopsis
- The study investigated how PCB 118 affects fish bone metabolism by measuring osteoclastic (bone resorbing) and osteoblastic (bone forming) activities, as well as calcium levels in goldfish.
- Results showed that after injecting PCB 118, osteoclastic activity significantly increased while osteoblastic activity remained unchanged, leading to elevated calcium levels in the fish.
- The findings suggest that PCB 118 disrupts bone metabolism in goldfish, both in living organisms and in laboratory conditions.
Article Abstract
To analyze the effect of polychlorinated biphenyl (PCB) 118 on fish bone metabolism, we examined osteoclastic and osteoblastic activities, as well as plasma calcium levels, in the scales of PCB (118)-injected goldfish. In addition, effect of PCB (118) on osteoclasts and osteoblasts was investigated in vitro. Immature goldfish, in which the endogenous effects of sex steroids are negligible, were used. PCB (118) was solubilized in dimethyl sulfoxide at a concentration of 10 ppm. At 1 and 2 days after PCB (118) injection (100 ng/g body weight), both osteoclastic and osteoblastic activities, and plasma calcium levels were measured. In an in vitro study, then, both osteoclastic and osteoblastic activities as well as each marker mRNA expression were examined. At 2 days, scale osteoclastic activity in PCB (118)-injected goldfish increased significantly, while osteoblastic activity did not change significantly. Corresponding to osteoclastic activity, plasma calcium levels increased significantly at 2 days after PCB (118) administration. Osteoclastic activation also occurred in the marker enzyme activities and mRNA expressions in vitro. Thus, we conclude that PCB (118) disrupts bone metabolism in goldfish both in vivo and in vitro experiments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021165 | PMC |
| http://dx.doi.org/10.1007/s11356-012-1347-5 | DOI Listing |
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