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Immune Thrombocytopenic Purpura Secondary to Cytomegalovirus (CMV) Infection: A Clinical Case.
Cureus
December 2024
General and Family Medicine, Câmara de Lobos Health Center, Serviço de Saúde da Região Autónoma da Madeira, Entidade Pública Empresarial da Região Autónoma da Madeira (SESARAM, EPERAM), Câmara de Lobos, PRT.
Immune thrombocytopenic purpura (ITP) is an autoimmune condition characterized by a reduced platelet count due to enhanced peripheral destruction and impaired platelet production. While thrombocytopenia is a well-documented complication of various viral infections, cytomegalovirus (CMV), a member of the Herpesviridae family, is primarily associated with infections in immunocompromised patients and is rarely implicated in causing severe thrombocytopenia in immunocompetent patients. This article aims to highlight the importance of considering CMV as a significant etiological factor in ITP, particularly in cases of asymptomatic thrombocytopenia.
View Article and Find Full Text PDFBowel-Associated Dermatosis-Arthritis Syndrome: A Report of a Rare Case.
Cureus
October 2024
Dermatology, Coimbra Local Health Unit, Coimbra, PRT.
Article Synopsis
- A 31-year-old woman with ulcerative colitis was readmitted to the hospital due to fever, joint pain, and skin lesions after her condition had improved.
- Histological tests confirmed she had neutrophilic dermatosis, leading to a diagnosis of bowel-associated dermatosis-arthritis syndrome (BADAS).
- BADAS is a rare condition linked to inflammatory bowel diseases and is treated with antibiotics and immunosuppressants, with recovery prospects tied to managing the underlying intestinal issue.
[Cutaneous ulcer as the initial manifestation of rheumatoid arthritis. Case report].
Rev Med Inst Mex Seguro Soc
May 2024
Instituto Mexicano del Seguro Social, Hospital de Traumatología y Ortopedia de Puebla, Servicio de Medicina Interna. Puebla, Puebla, México.
Background: 20-40% of patients with rheumatoid arthritis (RA) present an extra-articular manifestation (EAM) and 1-20% a severe EAM, with an increased risk of death (> 2 times). The associated lesions are: 27.5% rheumatoid nodules, and 0.
View Article and Find Full Text PDFCombination Doxycycline and Topical Corticosteroids in the Treatment of Ulcerative Pyoderma Gangrenosum: A Case Report.
Acta Med Philipp
September 2024
Department of Dermatology, Philippine General Hospital, University of the Philippines Manila.
Pyoderma gangrenosum (PG) is a chronic inflammatory neutrophilic dermatosis often presenting as a solitary enlarging painful ulcer with red to violaceous undermined borders. This report delves into the role of doxycycline in the treatment of PG in a 44-year-old male COVID-19 positive patient who has concomitant active tuberculosis infection and end-stage kidney disease, for which both first-line treatments (systemic corticosteroid and cyclosporine) are contraindicated. After three months on doxycycline and topical corticosteroids, there was resolution of the ulcers and no note of recurrence up to three months from completion of the treatment regimen.
View Article and Find Full Text PDFPyoderma Gangrenosum in an Ulcerative Colitis Patient on Vedolizumab.
Cureus
September 2024
Dermatology, Southwest Skin Specialists, Phoenix, USA.
Pyoderma gangrenosum is a rare neutrophilic dermatosis that presents as a tender, rapidly progressive ulcer with violaceous, undermined borders. Pathophysiology is multifactorial and has been suggested to involve neutrophil dysfunction, increased T-cell activation, and inflammatory mediator release, often in settings that are known to have autoimmune or genetic diseases. Some medications that modify the immune response have been described to trigger pyoderma gangrenosum.
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