Endophthalmitis remains the main complication of intravitreal injections, especially because their repetition multiplicates the risks. Surgical antisepsis is required for the prevention of endophthalmitis, but the benefit/risk ratio of topical antibioprophylaxis has never been demonstrated. In contrast, the selection of resistant bacteria appears to be exponential with the wider use of topical antibioprophylaxis. It seems that more and more operators stop using anibioprophylaxis, provided that the antisepsis is surgical and that the injection is performed in accordance with the rules of good practice.
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Antibioprophylaxis in Prevention of Endophthalmitis in Intravitreal Injection: A Systematic Review and Meta-Analysis.
PLoS One
August 2017
University Hospital of Clermont-Ferrand (CHU), Preventive and Occupational Medicine, Clermont-Ferrand, France.
Despite endophthalmitis being the most feared complication, antibioprophylaxis remains controversial in intravitreal injections. Therefore, we conducted a systematic review and meta-analysis on the effects of antibioprophylaxis in intravitreal injections in the prevention of endophthalmitis. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for studies comparing groups with and without antibiotics in intravitreal injection, with the use of the following keywords: "antibiotic*", "endophthalmitis" and "intravitreal injection*".
View Article and Find Full Text PDF[Prevention of post intravitreal injection endophthalmitis: is antibioprophylaxis indicated?].
J Fr Ophtalmol
January 2013
UMR-S 976, université Paris-Diderot, Sorbonne Paris-Cité, CHU Bichat-Fondation Rothschild, 25, rue Manin, 75019 Paris cedex 10, France.
Endophthalmitis remains the main complication of intravitreal injections, especially because their repetition multiplicates the risks. Surgical antisepsis is required for the prevention of endophthalmitis, but the benefit/risk ratio of topical antibioprophylaxis has never been demonstrated. In contrast, the selection of resistant bacteria appears to be exponential with the wider use of topical antibioprophylaxis.
View Article and Find Full Text PDF[Antibioprophylaxis in ocular surgery: AFSSAPS recommendations].
J Fr Ophtalmol
June 2011
Fondation Rothschild, hôpital Bichat, université Paris 7-Diderot, 25, rue Manin, 75019 Paris, France.
According to the literature and to the advice of experts, the French Agency for the Safety of Health Products (AFSSAPS) edited recommendations about the antibioprophylaxis in ocular surgery. One goal was to avoid the extensive use of oral and topical fluoroquinolones in antibioprophylaxis, in order to preserve their antibacterial activity for curative treatments of severe eye infections. The medical team decides for the indication and the type of antibioprophylaxis for each patient.
View Article and Find Full Text PDFLocal antimicrobial prophylaxis in cataract surgery: recent controversies and clinical guidelines.
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Service d'ophtalmologie, CHRU Dupuytren, Limoges, France.
The best prevention of endophthamitis is the use of strict surgical hygiene. Supplementing the irrigating solution with aminoglycosides and/or vancomycin is a rational, convenient and cost effective method of antimicrobial prophylaxis. However emerging resistance to vancomycin entails restrictions to its daily use.
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