Benzopyrano[2,3-b]pyridine is an important privileged medicinal scaffold. A three-component reaction of salicylaldehydes, thiols and 2 equiv of malononitrile that leads to the formation of a series of compounds incorporating 2,4-diamino-3-cyano-5-sulfanylbenzopyrano[2,3-b]pyridine framework is described. A proposed mechanism with the supporting experimental data is presented.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519924 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2006.10.110 | DOI Listing |
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