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http://dx.doi.org/10.1038/jes.2012.93 | DOI Listing |
Br J Clin Pharmacol
January 2025
Department of Medical Microbiology, Haaglanden Medisch Centrum, The Hague, The Netherlands.
Aims: The beta-lactam antibiotic temocillin is increasingly used to treat extended-spectrum beta-lactamase (ESBL-producing) strains; however, its protein binding is complex. This study aims to predict unbound temocillin concentrations in various participant groups to determine its impact on the probability of target attainment (PTA) and to improve dosing recommendations.
Methods: The plasma pharmacokinetics were analysed using non-linear mixed-effects modelling.
Antimicrob Steward Healthc Epidemiol
January 2025
Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Objective: To analyze antimicrobial prescribing practices in Australian emergency departments (ED), identifying prescribing areas requiring improvement. This aims to inform antimicrobial stewardship (AMS) strategies to enhance antimicrobial prescribing quality.
Design: Retrospective analysis of the Hospital National Antimicrobial Prescribing Survey (NAPS) data set.
Front Nutr
January 2025
Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, Guilin, China.
Aims: The association between urinary caffeine and caffeine metabolites with sex hormones remains unclear. This study used three statistical models to explore the associations between urinary caffeine and its metabolites and sex hormones among adults.
Methods: We selected the participants aged ≥18 years in the National Health and Nutrition Examination Survey (NHANES) data 2013-2014 as our study subjects.
Br J Health Psychol
February 2025
Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham School of Medicine and Birmingham VA Medical Center, Birmingham, Alabama, USA.
Objective: Mechanistic studies are needed to understand why depressive symptoms are associated with poorer physical health. The objective of this study was to examine whether behavioural, cognitive and physiological factors mediated an association between depressive symptoms, measured in early adulthood, and lower urinary tract symptoms (LUTS) and their impact, a composite variable measured in mid-life adulthood, among women in the Coronary Artery Risk Development in Young Adults study, conducted in four regions of the United States.
Design: Prospective cohort study.
BMC Neurol
January 2025
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Background: Guillain-Barré syndrome (GBS) presents with progressive ascending weakness, but it can also present with dysautonomia such as tachycardia, blood pressure fluctuations, diaphoresis, ileus, and urinary retention. GBS patients with dysautonomia was observed to have longer hospital stays and higher mortality rates than those without dysautonomia. We aimed to determine the risk factors for dysautonomia and its manifestations among patients with GBS and compared their features to those without dysautonomia.
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