Objective: To investigate the prevalence of zygapophysial joint pain in patients after disc surgery, and to determine the effectiveness of radiofrequency neurotomy for its treatment.
Design: Retrospective practice audit.
Setting: Review of charts of all patients who underwent lumbar disc surgery during a time period of 2 years.
Interventions: Patients with persistent back pain after surgery were tested with repeated medial branch blocks. Those patients who consistently report at least 80% pain relief underwent radiofrequency neurotomy. A successful outcome was defined as at least 50% pain reduction enduring for 6 months.
Results: In a population of 479 patients who underwent microsurgical lumbar disc operations, persistent axial back pain occurred in 120, of whom 34 had positive responses to diagnostic blocks and were treated with radiofrequency neurotomy. Twenty patients (58.8%) achieved at least 50% reduction in pain for a minimum of 6 months.
Conclusions: The prevalence of zygapophysial joint pain appears to be 7% in patients with failed back surgery syndrome. Patients with this condition can be treated with a radiofrequency neurotomy with a success rate of 58.8%.
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http://dx.doi.org/10.1111/pme.12012 | DOI Listing |
Biochem Biophys Res Commun
January 2025
Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Motor dysfunction in various diseases and aging is often accompanied by skeletal muscle atrophy and reduced axonal projections from motor neurons to the skeletal muscles. While several studies have investigated the correlations and molecular mechanisms between muscle atrophy and motor neuron denervation to explain the pathology of motor diseases, it remains unclear whether skeletal muscle atrophy directly causes axonal denervation of motor neurons. Here, we used a casts-attached mouse model which represents muscle atrophy and motor dysfunction in the hindlimbs to explore how skeletal muscle atrophy affects motor neuronal axon projections.
View Article and Find Full Text PDFHypertension
January 2025
Cardiology Department (P.B., X.L., V.T.T., M.A.B., A.V., E.Y., D.M.N., U.P., J.L., S.P.T., P.C.Q.), Westmead Hospital, Sydney, Australia.
Background: Transcatheter renal denervation (RDN) remains inconsistent despite developments in ablation technologies, due to the lack of an intraprocedural physiological end point.
Objective: To identify whether aorticorenal ganglion (ARG) guided RDN using microwave (MW) catheter leads to more consistent denervation outcomes compared with empirical MW ablation.
Methods: Pigs underwent sham procedure (n=8) or bilateral RDN using an in-house built open-irrigated MW catheter.
J Anus Rectum Colon
January 2025
Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Defecation disorders following rectal resection have long been overlooked as an inevitable surgical complication due to the lack of established diagnostic criteria or definitions. However, these disorders have been recently termed low anterior resection syndrome (LARS), which is a defecation disorder that occurs following rectal resection and impairs the patient's quality of life (QOL). The LARS score developed by Emmertsen et al.
View Article and Find Full Text PDFInsights Imaging
January 2025
IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Entrapment neuropathies at the elbow are common in clinical practice and require an accurate diagnosis for effective management. Understanding the imaging characteristics of these conditions is essential for confirming diagnoses and identifying underlying causes. Ultrasound serves as the primary imaging modality for evaluating nerve structure and movement, while MRI is superior for detecting muscle denervation.
View Article and Find Full Text PDFUnilateral whisker denervation activates plasticity mechanisms and circuit adaptations in adults. Single nucleus RNA sequencing and multiplex fluorescence in situ hybridization revealed differentially expressed genes related to altered glutamate receptor distributions and synaptogenesis in thalamocortical (TC) recipient layer 4 (L4) neurons of the sensory cortex, specifically those receiving input from the intact whiskers after whisker denervation. Electrophysiology detected increased spontaneous excitatory events at L4 neurons, confirming an increase in synaptic connections.
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