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Cardiopulmonary exercise response at high altitude in patients with congenital heart disease: a systematic review and meta-analysis.
Front Cardiovasc Med
December 2024
Department of Medicine DIMED, University of Padua, Padua, Italy.
Background: An increasing number of patients with congenital heart disease (CHD) engage in physical activities and may exercise at high altitudes (HA). The physiological adaptations required at HA and their implications on individuals with CHD, especially during exercise, remain underexplored. This systematic review aims to investigate cardiopulmonary exercise responses to short-term HA exposure in individuals with CHD.
View Article and Find Full Text PDFExploring Occupational Health Challenges in Pathology: A Cross-Sectional Survey of Indian Pathologists.
Cureus
December 2024
Pathology, BLDE (Deemed to be University) Shri B.M. Patil Medical College, Hospital, and Research Centre, Vijayapura, IND.
Introduction Occupational health hazards are a significant concern for pathologists due to their unique work environment. These professionals face risks from prolonged microscope use, exposure to chemicals such as formalin, and handling sharp instruments, leading to issues such as musculoskeletal disorders and needlestick injuries. Addressing these hazards is crucial for their well-being and the overall efficiency of medical diagnostics.
View Article and Find Full Text PDFUS Real-World Effectiveness, Tolerability, and Healthcare Resource Utilization After Addition of Fremanezumab for Preventive Treatment in Patients Using Gepants for Acute Treatment of Migraine: Results From a Retrospective Chart Review.
Adv Ther
January 2025
Dent Neurologic Institute, 3980 Sheridan Dr., Amherst, NY, 14226, USA.
Introduction: Fremanezumab, a monoclonal antibody (mAb) targeting the calcitonin gene-related peptide (CGRP) pathway, and gepants, small molecule CGRP receptor antagonists, are both approved for the treatment of migraine or its symptoms. This study assessed effectiveness, tolerability, and migraine-related healthcare resource utilization (HCRU) after the addition of fremanezumab for preventive migraine treatment in patients using gepants for acute treatment.
Methods: Data were extracted during a retrospective chart review from electronic medical records from the Dent Neurologic Institute.
Aerobic exercise and metformin attenuate the cognitive impairment in an experimental model of type 2 diabetes mellitus: focus on neuroinflammation and adult hippocampal neurogenesis.
Metab Brain Dis
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)- Kolkata, Kolkata, West Bengal, 700054, India.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that increases the prevalence of cognitive impairment in the geriatric population. Aerobic exercise is an excellent non-pharmacological therapeutic strategy to prevent Alzheimer's disease, the most common form of dementia. The exact molecular mechanism of aerobic exercise (Exe) as an intervention to counter cognitive decline is far from clear.
View Article and Find Full Text PDFClinical applications of 3D printing in spine surgery: a systematic review.
Eur Spine J
January 2025
In Silico Biomechanics Laboratory, National Center for Spinal Disorders, Buda Health Center, Budapest, Hungary.
Purpose: The objective of this systematic review is to present a comprehensive summary of existing research on the use of 3D printing in spinal surgery.
Methods: The researchers conducted a thorough search of four digital databases (PubMed, Web of Science, Scopus, and Embase) to identify relevant studies published between January 1999 and December 2022. The review focused on various aspects, including the types of objects printed, clinical applications, clinical outcomes, time and cost considerations, 3D printing materials, location of 3D printing, and technologies utilized.
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