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Quantifying the Relationship Between At-Home Shoulder Physiotherapy Participation and Outcome: What can a Watch Tell Us?
J Am Acad Orthop Surg
January 2025
From the Holland Bone and Joint Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (Boyer, Burns, Razmjou, Renteria, Sheth, Richards, and Whyne), the Division of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada (Burns, Sheth, Richards, and Whyne), the Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada (Boyer, Burns, and Whyne), the Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada (Razmjou), and the Sunnybrook Orthopaedic Upper Limb (SOUL), Sunnybrook Health Science Centre, Toronto, Ontario, Canada (Sheth, Richards, and Whyne).
Introduction: Exercise-based physiotherapy is an established treatment of rotator cuff injury. Objective assessment of at-home exercise is critical to understand its relationship with clinical outcomes. This study uses the Smart Physiotherapy Activity Recognition System to measure at-home physiotherapy participation in patients with rotator cuff injury based on inertial sensor data captured from smart watches.
View Article and Find Full Text PDFWhich Training Intensity Distribution Intervention will Produce the Greatest Improvements in Maximal Oxygen Uptake and Time-Trial Performance in Endurance Athletes? A Systematic Review and Network Meta-analysis of Individual Participant Data.
Sports Med
January 2025
Department of Sport Science and Physical Education, Faculty of Health and Sport Sciences, University of Agder, Kristiansand, Norway.
Background: Endurance athletes tend to accumulate large training volumes, the majority of which are performed at a low intensity and a smaller portion at moderate and high intensity. However, different training intensity distributions (TID) are employed to maximize physiological and performance adaptations.
Objective: The objective of this study was to conduct a systematic review and network meta-analysis of individual participant data to compare the effect of different TID models on maximal oxygen uptake (VO) and time-trial (TT) performance in endurance-trained athletes.
Head-to-Head comparison of [F]FDG, [F]FMZ, and [F]SynVesT-1 positron emission tomography imaging in patients with drug-resistant epilepsy.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Purpose: The loss of synaptic vesicle glycoprotein 2 A (SV2A) can lead to dysfunction of GABAergic neurons, but a direct comparison of SV2A and GABA receptor densities in humans has not been assessed. This study evaluated SV2A and GABA receptor abnormalities in patients with drug-resistant epilepsy (DRE) and compared the patterns to glucose hypometabolism.
Methods: Eleven patients with DRE were retrospectively recruited and underwent PET imaging with [F]fluorodeoxyglucose ([F]FDG), [F]Flumazenil (FMZ), and [F]SynVesT-1.
Informed Consent in Pelvic Reconstructive Surgery: Patients' Perspective of a Tertiary Service Process.
Int Urogynecol J
January 2025
Department of Urogynaecology, Cambridge University Hospitals NHS Foundation Trust, Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK.
Introduction And Hypothesis: Obtaining informed consent to surgery is essential for ethical, legal, and quality-care reasons. This study evaluates patients' understanding, experience, and satisfaction with the informed consent process prior to pelvic reconstructive surgery.
Methods: A prospective study was conducted from April 2021 to April 2022, registered as a service evaluation project.
Comprehensive Single-Cell Chromatin and Transcriptomic Profiling of Peripheral Immune Cells in Non-Segmental Vitiligo.
Br J Dermatol
January 2025
Inflammatory Immune-Mediated Chronic Skin Diseases Laboratory (GC26), Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba/Reina Sofia University Hospital, Menendez Pidal Ave, 14004, Córdoba, Spain.
Introduction: Non-segmental vitiligo (NSV) is an autoimmune condition characterized by melanocyte loss. While skin-specific mechanisms are well-studied, systemic immune dysregulation contributing to NSV pathogenesis remains unclear.
Objective: This study employs a multi-omic single-cell approach to investigate circulating immune cells in NSV, integrating transcriptional and chromatin accessibility data.
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