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Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease.
J Immunol
December 2023
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
Article Synopsis
- Platelets play a significant role in allergic asthma and aspirin-exacerbated respiratory disease (AERD) by being activated and influencing inflammatory responses.
- The study found that the GLP-1 receptor (GLP-1R) agonist liraglutide reduced platelet activation and airway resistance in a mouse model of AERD, indicating its potential therapeutic benefits.
- Liraglutide showed promise in inhibiting platelet activation in both mice and human patients with AERD, suggesting that targeting the GLP-1R could be a new strategy for managing asthma-related inflammation.
Heterozygous nonsense variants in the ferritin heavy-chain gene FTH1 cause a neuroferritinopathy.
HGG Adv
October 2023
Division of Neurology and Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Epilepsy Neurogenetics Initiative (ENGIN), The Children's Hospital of Philadelphia and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
Ferritin, the iron-storage protein, is composed of light- and heavy-chain subunits, encoded by FTL and FTH1, respectively. Heterozygous variants in FTL cause hereditary neuroferritinopathy, a type of neurodegeneration with brain iron accumulation (NBIA). Variants in FTH1 have not been previously associated with neurologic disease.
View Article and Find Full Text PDFHeterozygous Nonsense Variants in the Ferritin Heavy Chain Gene Cause a Novel Pediatric Neuroferritinopathy.
medRxiv
January 2023
Division of Neurology and Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Ferritin, the iron storage protein, is composed of light and heavy chain subunits, encoded by and , respectively. Heterozygous variants in cause hereditary neuroferritinopathy, a type of neurodegeneration with brain iron accumulation (NBIA). Variants in have not been previously associated with neurologic disease.
View Article and Find Full Text PDFDifferential sensing with arrays of de novo designed peptide assemblies.
Nat Commun
January 2023
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Differential sensing attempts to mimic the mammalian senses of smell and taste to identify analytes and complex mixtures. In place of hundreds of complex, membrane-bound G-protein coupled receptors, differential sensors employ arrays of small molecules. Here we show that arrays of computationally designed de novo peptides provide alternative synthetic receptors for differential sensing.
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