Objective: Self-rated health (SRH) reflects lifestyle habits, chronic disease, and psychosocial conditions. The aim of this study was to examine the relationship between transitions in SRH and health indicators among Japanese white-collar workers.

Methods: Three-year medical examination data from an occupational field was used. The distribution of data related to SRH, lifestyle habits, treatment of chronic disease, laboratory data abnormalities, job stress, and sickness absences were compared using ridit analysis, and the odds ratios and 95% confidence intervals were calculated using the first year of observation as a reference.

Results: During the observation period, the proportion of workers with poor SRH, self-rated lifestyle habits, sleep, dietary habits, and body mass index increased. Particularly, high job stress (heavy job burden and low job control) and few sickness absences were strongly related to poor SRH.

Conclusions: Unfavorable lifestyles and work-related conditions worsened as SRH declined among workers. The results suggest that health indicators related to SRH are different according to the population. Tracking changes in SRH using indices related to SRH is useful for evaluating the health status in a target group.

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