Objective: Recent evidence indicates that heat-enhanced food advanced glycation end products (AGEs) adversely affect vascular function. The aim of this study was to examine the acute effects of an oral load of heat-treated, AGE-modified β-lactoglobulins (AGE-BLG) compared with heat-treated, nonglycated BLG (C-BLG) on vascular function in patients with type 2 diabetes mellitus (T2DM).
Research Design And Methods: In a double-blind, controlled, randomized, crossover study, 19 patients with T2DM received, on two different occasions, beverages containing either AGE-BLG or C-BLG. We measured macrovascular [brachial ultrasound of flow-mediated dilatation (FMD)] and microvascular (laser-Doppler measurements of reactive hyperemia in the hand) functions at baseline (T0), 90 (T90), and 180 (T180) min.
Results: Following the AGE-BLG, FMD decreased at T90 by 80% from baseline and remained decreased by 42% at T180 (P < 0.05 vs. baseline, P < 0.05 vs. C-BLG at T90). By comparison, following C-BLG, FMD decreased by 27% at T90 and 51% at T180 (P < 0.05 vs. baseline at T180). A significant decrease in nitrite (T180) and nitrate (T90 and T180), as well as a significant increase in N(ε)-carboxymethyllisine, accompanied intake of AGE-BLG. There was no change in microvascular function caused by either beverage.
Conclusions: In patients with T2DM, acute oral administration of a single AGE-modified protein class significantly though transiently impaired macrovascular function in concert with decreased nitric oxide bioavailability. These AGE-related changes were independent of heat treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631855 | PMC |
| http://dx.doi.org/10.2337/dc12-1489 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The development and validation of a Japanese hazard perception task.
Traffic Inj Prev
January 2025
Soen Driving School, Hokkaido, Japan.
Objectives: This study aimed to validate the hazard perception task developed for Japanese drivers with brain damage.
Methods: A total of 36 professional driving instructors, 67 older adult drivers, 39 young drivers, and 72 patients with brain damage participated in the study. A video-based hazard perception task measured the hazard perception skills of each group.
Analyzing the effectivity of evidence-based practice in health science higher education: a narrative review.
Sao Paulo Med J
January 2025
Professor, Master's Program in Innovation in Higher Education in Health, Universidade Municipal de São Caetano do Sul (USCS), São Caetano do Sul (SP), Brazil.
Background: Although multiple strategies have been suggested for evidence-based practice educational interventions, few studies have focused on the development of abilities for evidence-based practice implementation.
Objective: To explore the effectiveness of evidence-based practice in higher education and understand its teaching methods.
Design And Setting: Narrative review was conducted at the Universidade Municipal de São Caetano do Sul, Brazil.
Effects of rapid maxillary expansion on auditory thresholds and middle ear functioning.
Codas
January 2025
Instituto de Psicologia, Serviço Social, Saúde e Comunicação Humana, Universidade Federal do Rio Grande do Sul - UFRGS - Porto Alegre (RS), Brasil.
Purpose: To ascertain whether Rapid Maxillary Expansion (RME) elicits effects on the functioning of the middle ear and air-bone gaps in children and adolescents.
Methods: Single-arm clinical trial, with data collection at four time points: before initiating Rapid Maxillary Expansion (RME) (T0), upon completion of RME (T1), three months post-RME completion (T2), and six months post-RME procedure (T3). The audiological assessment, conducted at all four time points, comprised otoscopy, pure tone and speech audiometry, tympanometry, and acoustic reflex investigation.
Retinopathy of prematurity: Accuracy of ROPScore and WINROP algorithms in a Brazilian population.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: To assess the sensitivity and specificity of the retinopathy of prematurity score (ROPScore) and weight, insulin-like growth factor-1, retinopathy of prematurity algorithm in predicting the risk of developing severe retinopathy of prematurity (prethreshold type 1) in a sample of preterm infants in Brazil.
Methods: Retrospective analysis of medical records of preterm infants (n=288) with birth weight of ≤1500 g and/or gestational age of 23-32 weeks in a neonatal unit in Southern Brazil from May 2013 to December 2020 (92 months).
Results: The incidence of confirmed severe retinopathy of prematurity was 6.
Acellular Dermal Matrices in Reconstructive Pediatric Complex Lower Limb Trauma: An Observational Study.
J Trauma Nurs
January 2025
Author Affiliations: St Andrew's Anglia Ruskin (StAAR) Research Group, Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford, UK (Dr Adegboye); Division of Plastic and Reconstructive Surgery, Red Cross War Memorial Children's Hospital; and Division of Plastic & Reconstructive Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa (Dr Pillay and Prof Adams).
Background: Contemporary research has shown that acellular dermal matrices can benefit adult lower extremity traumatic injuries; however, its use in children has not been explored.
Objective: This study aims to explore the use of acellular dermal matrices in pediatric complex lower extremity trauma.
Methods: This single-center retrospective observational cohort study of children with complex lower extremity trauma treated with Pelnac™, commercial acellular dermal matrices, was conducted at a tertiary hospital in South Africa from 2010 to 2017.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!