AI Article Synopsis
- Mothers can tolerate fetal tissues during pregnancy due to multiple immune mechanisms, primarily through HLA-G molecules that help shift the maternal immune response toward tolerance.
- Researchers discovered a specific type of dendritic cell, called DC-10, which secretes IL-10 and expresses high levels of HLA-G and ILT4, playing a key role in developing regulatory T cells.
- The study found that DC-10 and HLA-G-expressing CD4(+) T cells are more abundant in the human decidua during the first trimester compared to peripheral blood, indicating their importance in promoting immune tolerance at the fetal-maternal interface.
Article Abstract
Multiple mechanisms underlie the surprising willingness of mothers to tolerate the semi-allogeneic fetal tissues during pregnancy. Chief among these is the expression of the HLA-G molecules that has been largely demonstrated to be responsible for reprogramming the local maternal immune response towards tolerance. We recently identified a subset of tolerogenic dendritic cells, DC-10 that secrete high amounts of IL-10 and express high levels of HLA-G and its ligand ILT4. DC-10 are present in the peripheral blood and are essential in inducing adaptive regulatory T cells. We investigated the presence of DC-10 and HLA-G-expressing CD4(+) T cells in human decidua in the first trimester of pregnancy. Results showed that these cells are highly represented in human decidua as compared to the peripheral blood. This is the first report describing decidual DC-10 and CD4(+)HLA-G(+) T cells, strongly suggesting that they may accumulate or be induced at the fetal maternal interface to promote tolerance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610019 | PMC |
| http://dx.doi.org/10.1016/j.humimm.2012.11.031 | DOI Listing |
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